Pyridopyridazines. III. Pyrido [3, 4-d] pyridazines. I.

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3-(4-Meth­oxy­phen­yl)pyrido[2,3-b]pyrazine

In the title mol-ecule, C(14)H(11)N(3)O, the benzene ring is twisted by 14.0 (2)° from the plane through the fused ring system. In the crystal, π-π inter-actions [centroid-centroid distances = 3.609 (1), 3.639 (1) and 3.735 (1) Å] form stacks of mol-ecules propagating along the b axis. The crystal packing is further stabilized by weak inter-molecular C-H⋯O and C-H⋯N hydrogen bonds.

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2-(4-Fluoro­phen­yl)-3-(4-pyrid­yl)pyrido[2,3-b]pyrazine

In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine system makes dihedral angles of 45.51 (7) and 44.75 (7)° with the attached 4-fluoro-phenyl ring and the pyridine ring, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 54.54 (8)° with the pyridine ring. The pyridine ring part of the pyridopyrazine ring and the pyrazine ring of two c-glide-plane-r...

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3-(4-Fluoro­phen­yl)-2-(4-pyrid­yl)pyrido[2,3-b]pyrazine

In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine ring makes dihedral angles of 34.67 (7) and 52.24 (7)° with the 4-fluoro-phenyl and pyridine rings, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 59.56 (9)° with the pyridine ring.

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Spiro­[cyclo­pentane-1,2′(1′H)-pyrido[2,3-d]pyrimidin]-4′(3′H)-one

The title compound, C(11)H(13)N(2)O, was obtained by cyclo-condensation of 2-amino-pyridine-3-carbonitrile with cyclo-penta-none. The mol-ecule is built up from two fused six-membered rings and one five-membered ring linked through a spiro C atom. Both the pyrimidine and the cyclo-pentane rings adopt envelope conformations. In the crystal structure, mol-ecules are linked by inter-molecular N-H⋯...

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6′-Bromo-1′H-spiro­[cyclo­hexane-1,2′-pyrido[2,3-d]pyrimidin]-4′(3′H)-one

The title compound, C(12)H(14)BrN(3)O, is built up from two fused six-membered rings and one six-membered ring linked through a spiro C atom. The hydro-pyrimidine ring has an envelope conformation and the cyclo-hexane ring is in a chair conformation. In the crystal, mol-ecules are linked by N-H⋯O and N-H⋯N hydrogen bonds, forming a mol-ecular tape along the b axis.

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 1969

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.17.2266